This article has been cited by other articles in PMC. Abstract Complementary and alternative medicine includes a number of exercise modalities, such as tai chi, qigong, yoga, and a variety of lesser-known movement therapies.
Click Here to receive the latest FM News via e-mail Two proteins linked to inflammation and oxidative stress are deregulated in blood samples of fibromyalgia FM patients compared with healthy controls, according to findings from a large-scale protein analysis.
Specifically, the levels of these two proteins, called haptoglobin and fibrinogen, which respond to inflammation, were found to be increased in fibromyalgia patients and may work as biomarkers for a faster and more timely diagnosis, the researchers suggest. The underlying cause of fibromyalgia, a disease characterized by widespread muscle pain and fatigue, remains unknown; however, several factors are known to contribute to the condition.
Among these factors, inflammation and oxidative stress are the most frequently reported. The complexity of factors contributing to fibromyalgia represent an added difficulty to treatment and even diagnosis of the disease — it can take up to five years for patients to be diagnosed.
This highlights the need to find good markers that may assist in identifying fibromyalgia in a more timely manner so that appropriate treatments are administered promptly. In this study, researchers used a technique called proteomics to identify and measure potential changes in proteins in the blood of fibromyalgia patients.
This approach allows researchers to screen all proteins present on a large scale in a given sample.
The study enrolled 12 women with fibromyalgia and 12 age-matched healthy women as controls. The blood samples used for the proteomics analysis were retrieved from both groups in the early morning after an overnight fast to avoid fluctuations that can occur throughout the day. The proteomics analysis identified a total of proteins, of which 33 were different between fibromyalgia patients and controls: The major signaling pathways altered in fibromyalgia patients included acute-phase response signaling, coagulation, and complement systems.
The haptoglobin and fibrinogen proteins, which belong to this signaling pathway, were particularly elevated in fibromyalgia patients relative to controls.
These receptors are involved in several processes, but have been reported to exert an anti-inflammatory action.Methods. An analysis to determine the feasibility, reliability, and validity of the PedsQL™ (Pediatric Quality of Life Inventory™) Generic Core Scales, PedsQL™ Multidimensional Fatigue Scale, and PedsQL™ Rheumatology Module Pain and Hurt Scale as patient-reported outcome (PRO) measures for pediatric patients with fibromyalgia.
Fibromyalgia; Synonyms: Fibromyalgia syndrome (FMS) obesity and lack of physical activity may increase the risk of an individual developing fibromyalgia. A meta analysis found psychological trauma to be associated with FM, although not as strongly as in chronic fatigue syndrome.
Fibromyalgia is a complex pain syndrome that currently does not hold an exact definition. Its multidimensionality stems from the broad spectrum of symptoms including widespread pain, tenderness, fatigue, sleep problems, musculoskeletal stiffness, cognitive dysfunction, environmental sensitivity, mood disorders including depression, poor balance, muscle weakness, disability and functional impairment [ .
The aim of this paper was to compare the efficacy of the treatments for fibromyalgia currently available in both primary care and specialised settings. Published reports of randomised controlled trials (RCTs) researching pharmacological and non-pharmacological treatments in patients with fibromyalgia were found in the MEDLINE, .
Sep 06, · Fibromyalgia is currently understood to be a disorder of central pain processing or a syndrome of central sensitivity. Clauw describes the syndrome as a diffuse problem of sensory “volume control” such that patients have a lower threshold of pain and of other stimuli, such as heat, noise, and strong odors.
Methods: This meta-analysis of 49 fibromyalgia treatment outcome studies assessed the efficacy of pharmacological and nonpharmacological treatment across four types of outcome measures—physical status, self-report of FMS symptoms, psychological status, and daily functioning.